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Calculation of IC50: CA 02706018 2010-05-17 WO 2009/068617 PCT/EP2008/066350 - 49 - 1050 can be calculated in a conventional way, eventually with the help of GraphPadPrism or other suited software setting the positive control as 100 and the negative control as 0. For calculation of 1050 usually 8 dilutions of the test compound (substrates) are to be selected and tested following the aforementioned protocol, ostarine mk-2866 como tomar. For to illustrate the pharmacological properties of the compounds according to the present invention in the following are given some illustrative and representative examples thereof, which are not considered to be limiting. CA 02706018 2010-05-17 WO 2009/068617 PCT/EP2008/066350 - 50 - 29 89 between 10 and 500 9 30 95 between 10 and 500 8 30-1 101 between 10 and 500 55 30-2 100 between 10 and 500 55 30-3 100 between 10 and 500 14 30-4 99 between 10 and 500 3 30-5 97 between 10 and 500 26 31 82 more than 500 8 32 91 between 10 and 500 11 33 89 between 10 and 500 4 34 60 more than 500 19 35 93 between 10 and 500 10 36 98 between 10 and 500 54 37 99 between 10 and 500 27 38 92 more than 500 9 39 97 between 10 and 500 4 *for illustrative purposes The in vivo effect of the compounds of this invention can be tested in the Novel Object Recognition test according to the procedure of Prickaerts et al. CHEMICAL MANUFACTURE Abbreviations: DIPEA di-isopropyl-ethylamine DMSO dimethyl sulph oxide ESI electrospray ionization (in MS) h hour(s) HPLC high performance liquid chromatography HPLC-MS coupled high performance liquid chromatography-mass spectroscopy MPLC medium pressure liquid chromatography min minutes MS mass spectroscopy Psi pounds per square inch. Le dveloppement d'un programme ducatif, "vis au changement de l'opinion publique au problme de doper", devrait faire partie du plan collectif du Ministre de Sports et du Conseil de l'Europe, dont les discussions ont continu depuis le dbut de mai, ostarine mk-2866 como tomar.
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